PLATELET FUNCTION ACTIVATED BY OZONE IN TISSUE REGENERATION

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PLATELET FUNCTION.

Platelets are mainly known for their role in the process of hemostasis which help prevent blood loss in vascular areas wounds. To carry it out, platelets adhere, aggregate and form a pro-coagulant surface, which causes the generation of thrombin and fibrin formation. The formation of a hematoma or blood clot (eschar) begins the healing cascade.

PLATELET RICH PLASMA (PRP).

The Platelet Rich Plasma (PRP) is defined as the portion of the plasma fraction of autologous blood you obtained by centrifuging and it have a concentration higher of platelet. The PRP contains not only platelets also is formed by: plasma, leukocytes, growth factors and secretory proteins all components of the coagulation cascade. The PRP can potentially enhance the recruitment and proliferation of stem cells and endothelial cells.

GROWTH FACTORS (PDGF).

The sites of platelets known by name (Alpha granules of Platelets) contain the growth factors.  Are they polypeptide that stimulates the replication of normal connective tissue cells what include:

  • The growth factor-beta (TGF-b).
  • The vascular endothelial growth factor (VEGF).
  • The transforming growth factor beta; (PDAF), angio-genic platelet-derived Factor; IGF-1, insulin-like growth factor 1; EGF, epidermal growth factor; FGF, fibroblast growth factor; PF-4, platelet factor 4.

WHY USE PLATELET-RICH-PLASMA?

The treatment of autologous platelet-rich plasma (PRP),  it resembles the natural process of healing for example:  when we are in the presence of a wound and the healing process begins below the eschar produced by coagulation of the patient’s blood. This process is safe due to its autologous nature.

HOW TO RELEASE GROWTH FACTORS?

In studies by Dr. Bocci (1999) It has been proven what the heparin, in the presence of ozone (O3), promotes a dose-dependent platelet aggregation and this results has allowed Ozone use for to trigger the release of growth factors in the platelets.

CONCLUSIONS OF USE.

The enhancement of tissue healing by the placement of supra-physiologic concentration of autologous platelets at the site of tissue injury or surgery is supported by basic science and clinical studies. Due to the increased concentration and release of these factors, PPR can potentially enhance the recruitment and proliferation of stem cells and endothelial cells.

Ozone can promote platelet aggregation and release of grow factors. In addition to use in the treatment of chronic skin and soft tissue ulcerations, application of this method include periodontal and oral surgery, maxillofacial surgery, orthopedic and trauma surgery, cosmetic and plastic surgery, spinal surgery, heart bypass surgery, and burns.

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(PDGF) Released by Ozone

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AS THE RESULT OF INVESTIGATIONS THE BIOCHEMISTRY OF BLOOD.

Platelets are specialized blood cells that play central roles in physiologic and pathologic processes of hemostasis, inflammation, tumor metastasis, wound healing, and host defense. Within platelets the alpha-granular contents are destined for release during platelet activation at sites of vessel wall injury and thus play an important role in homeostasis, inflammation, ultimate wound repair and in the pathogenesis of atherosclerosis.

Therefore the Alpha granules of Platelets contain a polypeptide growth factor that stimulates the replication of normal connective tissue cells; this platelet-derived growth factor (PDGF) we can release it during the activation reaction with the gas ozone.

APPLICATIONS

In articular cartilage, numerous growth factors work in concert to regulate development and homeostasis of articular cartilage throughout life. The use of bio-active growth factors is under consideration as a potential therapy to enhance healing of chondral injuries and modify the arthritic disease process.Therefore, growth factors offer promising treatments for enhanced regeneration of cartilage in focal articular cartilage defects or in situations of more widespread cartilage loss such as those that occur in osteoarthritis (OA).